PECAM-1/IgG attenuates peroxynitrite-mediated extremity reperfusion injury
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چکیده
منابع مشابه
Peroxynitrite attenuates hepatic ischemia-reperfusion injury.
In the present study, we examined the effects of peroxynitrite on reperfusion injury using a rat model of hepatic ischemia-reperfusion (HI/R). The left and median lobes of the liver were subjected to 30 min of ischemia, followed by 4 h of reperfusion. Groups A and B rats were sham-operated controls that received vehicle or peroxynitrite; groups C and D rats were subjected to HI/R and received p...
متن کاملLipid peroxidation and peroxynitrite in retinal ischemia-reperfusion injury.
PURPOSE To investigate whether lipid peroxides play a role in retinal cell death due to ischemia-reperfusion injury, whether recombinant human thioredoxin (rhTRX) treatment reduces production of lipid peroxides of the retina, and whether such treatment reduces the number of cells expressing c-Jun and cyclin D1. METHODS Retinal ischemia was induced in rats by increasing the intraocular pressur...
متن کاملMycophenolate mofetil attenuates renal ischemia/reperfusion injury.
Immunosuppressive agents may have an impact on ischemia/reperfusion (I/R) injury. The immunosuppressant mycophenolate mofetil (MMF) presents properties that can attenuate such injury. This study investigated the effects of MMF on renal I/R injury. Male Wistar rats received MMF (20 mg/kg per d) or vehicle by gavage beginning 2 d before ischemia and maintained during the entire study. Ischemic in...
متن کاملCurcumin attenuates myocardial ischemia–reperfusion injury
Background Cardiovascular diseases (CVDs) are at a badly high-risk of morbidity and mortality in the world. Methods Our study was attempted to investigate the cardioprotective role of curcumin. Hearts injury was assessed in isolated hearts and the rats of coronary artery ligated. Results and Conclusions The inhibition of pro-inflammatory cytokines was observed by curcumin in coronary artery...
متن کاملHesperidin pre-treatment attenuates NO-mediated cerebral ischemic reperfusion injury and memory dysfunction.
The present study was designed to explore the mechanism of hesperidin action via the nitric oxide pathway in the protection against ischemic reperfusion cerebral injury-induced memory dysfunction. Male Wistar rats (200-220 g) were subjected to bilateral carotid artery occlusion for 30 min followed by 24 h reperfusion. Hesperidin (50 and 100 mg/kg, po) pretreatment was given for 7 days before an...
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ژورنال
عنوان ژورنال: Journal of Vascular Surgery
سال: 2001
ISSN: 0741-5214
DOI: 10.1067/mva.2001.115813